Motif ID: NFY{A,B,C}.p2

Z-value: 2.545


Transcription factors associated with NFY{A,B,C}.p2:

Gene SymbolEntrez IDGene Name
NFYA 4800 nuclear transcription factor Y, alpha
NFYB 4801 nuclear transcription factor Y, beta
NFYC 4802 nuclear transcription factor Y, gamma

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NFYCchr1_+_412045090.393.5e-02Click!
NFYAchr6_+_410406870.346.6e-02Click!
NFYBchr12_-_1045318750.319.1e-02Click!


Activity profile for motif NFY{A,B,C}.p2.

activity profile for motif NFY{A,B,C}.p2


Sorted Z-values histogram for motif NFY{A,B,C}.p2

Sorted Z-values for motif NFY{A,B,C}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFY{A,B,C}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_+_54863672 9.016 NM_001130851
NM_005192
CDKN3

cyclin-dependent kinase inhibitor 3

chr17_-_38574042 7.350 NM_001067
TOP2A
topoisomerase (DNA) II alpha 170kDa
chr17_+_6347733 7.264 NM_001195228
NM_019013
FAM64A

family with sequence similarity 64, member A

chr19_-_14247400 7.245 NM_018154
ASF1B
ASF1 anti-silencing function 1 homolog B (S. cerevisiae)
chr2_+_10262853 7.241 NM_001034
RRM2
ribonucleotide reductase M2
chr2_+_27008912 6.857 CENPA
centromere protein A
chr17_+_57232859 6.619 NM_018304
PRR11
proline rich 11
chr19_+_4910339 6.354 NM_013282
UHRF1
ubiquitin-like with PHD and ring finger domains 1
chr6_+_80714389 6.333 TTK
TTK protein kinase
chr2_+_10262694 6.191 NM_001165931
RRM2
ribonucleotide reductase M2
chr6_+_80714321 6.125 NM_001166691
NM_003318
TTK

TTK protein kinase

chr17_-_76183074 5.968 NM_003258
TK1
thymidine kinase 1, soluble
chr15_-_41624760 5.808 NM_007280
OIP5
Opa interacting protein 5
chr19_-_14247267 5.784 ASF1B
ASF1 anti-silencing function 1 homolog B (S. cerevisiae)
chr5_+_162887516 5.607 NM_001142556
NM_001142557
NM_012484
NM_012485
HMMR



hyaluronan-mediated motility receptor (RHAMM)



chr20_+_30326903 5.499 NM_012112
TPX2
TPX2, microtubule-associated, homolog (Xenopus laevis)
chr5_+_68462948 5.469 CCNB1
cyclin B1
chr17_+_26646120 5.405 NM_014573
TMEM97
transmembrane protein 97
chr15_+_41625052 5.192 NUSAP1
nucleolar and spindle associated protein 1
chr15_+_41624891 5.191 NM_001243142
NM_001243143
NM_001243144
NM_016359
NM_018454
NUSAP1




nucleolar and spindle associated protein 1





Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 123 entries
enrichment   p-value GO term description
8.43 6.91e-03 GO:0000085 G2 phase of mitotic cell cycle
8.43 6.91e-03 GO:0051319 G2 phase
6.78 1.30e-08 GO:0006695 cholesterol biosynthetic process
6.34 4.50e-09 GO:0016126 sterol biosynthetic process
5.59 2.60e-04 GO:0006271 DNA strand elongation involved in DNA replication
5.22 7.09e-04 GO:0022616 DNA strand elongation
4.93 1.08e-05 GO:0000819 sister chromatid segregation
4.79 1.02e-11 GO:0000236 mitotic prometaphase
4.70 1.76e-04 GO:0000070 mitotic sister chromatid segregation
4.52 1.29e-02 GO:0000724 double-strand break repair via homologous recombination
4.52 1.29e-02 GO:0000725 recombinational repair
4.25 2.69e-02 GO:0031110 regulation of microtubule polymerization or depolymerization
4.21 6.58e-11 GO:0007059 chromosome segregation
4.18 5.17e-04 GO:0007051 spindle organization
3.90 6.17e-28 GO:0000087 M phase of mitotic cell cycle
3.75 1.47e-24 GO:0000280 nuclear division
3.75 1.47e-24 GO:0007067 mitosis
3.71 7.36e-03 GO:0070507 regulation of microtubule cytoskeleton organization
3.63 1.89e-23 GO:0048285 organelle fission
3.56 1.08e-32 GO:0000279 M phase

Gene overrepresentation in compartment category:

Showing 1 to 20 of 56 entries
enrichment   p-value GO term description
7.67 2.97e-03 GO:0000780 condensed nuclear chromosome, centromeric region
4.82 5.79e-08 GO:0000794 condensed nuclear chromosome
4.38 2.76e-09 GO:0000779 condensed chromosome, centromeric region
4.38 8.88e-08 GO:0000922 spindle pole
4.35 1.88e-08 GO:0000777 condensed chromosome kinetochore
4.25 1.52e-16 GO:0000793 condensed chromosome
4.11 3.31e-09 GO:0000776 kinetochore
3.65 1.19e-11 GO:0000775 chromosome, centromeric region
3.53 3.77e-02 GO:0008287 protein serine/threonine phosphatase complex
3.43 7.61e-13 GO:0005819 spindle
3.27 7.52e-03 GO:0030496 midbody
3.19 3.28e-03 GO:0034399 nuclear periphery
3.11 1.48e-02 GO:0016363 nuclear matrix
2.91 1.41e-07 GO:0044454 nuclear chromosome part
2.81 9.56e-09 GO:0000228 nuclear chromosome
2.55 4.63e-18 GO:0005694 chromosome
2.54 3.91e-02 GO:0032993 protein-DNA complex
2.52 2.28e-14 GO:0044427 chromosomal part
2.37 3.86e-05 GO:0005813 centrosome
2.17 2.65e-04 GO:0005759 mitochondrial matrix

Gene overrepresentation in function category:

Showing 1 to 20 of 23 entries
enrichment   p-value GO term description
10.04 1.55e-02 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
4.82 1.53e-03 GO:0004003 ATP-dependent DNA helicase activity
4.22 1.46e-03 GO:0003678 DNA helicase activity
3.59 1.55e-03 GO:0003697 single-stranded DNA binding
3.25 6.96e-03 GO:0008094 DNA-dependent ATPase activity
2.26 9.47e-03 GO:0000287 magnesium ion binding
2.15 1.55e-02 GO:0043566 structure-specific DNA binding
1.60 2.09e-03 GO:0017111 nucleoside-triphosphatase activity
1.59 1.52e-03 GO:0016817 hydrolase activity, acting on acid anhydrides
1.58 2.25e-03 GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
1.57 3.30e-03 GO:0016462 pyrophosphatase activity
1.51 3.02e-06 GO:0030554 adenyl nucleotide binding
1.51 5.05e-06 GO:0005524 ATP binding
1.50 5.64e-06 GO:0032559 adenyl ribonucleotide binding
1.43 4.55e-07 GO:0000166 nucleotide binding
1.43 3.33e-05 GO:0035639 purine ribonucleoside triphosphate binding
1.42 3.03e-05 GO:0017076 purine nucleotide binding
1.42 4.84e-05 GO:0032553 ribonucleotide binding
1.42 4.84e-05 GO:0032555 purine ribonucleotide binding
1.26 3.49e-14 GO:0005515 protein binding